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Although no important variations were located in tyrosine hydroxylase activity and expression, brain tissue levels of three,four-dihydroxyphenylalanine had been threefold increased in α2A- and α2C-adrenoceptor KO mice. Brain tissue amounts of dopamine and noradrenaline were considerably better in α2A and α2CKOs in contrast with WT [WT: 2.Your H